Friday, November 30, 2012

Home Improvements for Big Spaces

8 hours ago, in Home & Garden

stairsBuying a bigger house block is always a great investment. In fact, you may consider saving money by building your own kit home, so you can spend more on the land. But there is always a difficult balance between enjoying the space and using the space to its full advantage. If you have the big block and aren?t sure what to do with it, here are some ideas:

Vegetable Gardens

Putting in vegetable gardens will see you saving money on produce, as well as giving your kids or grandchildren the thrill of growing their own food. This, in turn, will encourage healthy eating habits.

Depending on the space you have, this might go from a single garden bed to rows of beds. It is possible to build your own beds from scratch using recycled timber or you can put in block beds. Seek advice on types of wood, tin and block that are suitable, as the materials will be exposed to water, fertilisers and plenty of sunshine.

You may also be able to enhance the area with some paving and cut down on mowing between the beds. Consider the location of the garden beds as well and which areas of the yard catch the best sun in all seasons. Installing an irrigation system is an excellent idea to avoid losing produce for want of time to water. Also think about incorporating a compost bin, and possibly even a small garden shed.

Playground and Gazebo

Having a deck or entertaining area set off the back door is a terrific idea, but have you considered a stand-alone staged gazebo in the backyard? A gazebo offers an idyllic shaded spot for meditation, reading and entertaining guests. Gazebos can be landscaped in almost any style, from Balinese to Victorian.

If you?re thinking about adding this type of relaxation area, it may be worth considering putting in a fort or playground close by. A play area for the kids is no longer relegated to a rusty, old swing set. Features that can be added include a giant chequerboard or cubbyhouse. A gazebo with an accompanying playground means you can enjoy a cuppa while the kids blow off some steam in the fresh air.

Pool and Entertaining

Extra space allows you to extend your outdoor living into a pool and entertainment area. As your home flows out into a deck or tiled outdoor kitchen, friends and family can enjoy cooling off in the pool. This sort of area can be used for lunchtime barbeques with the kids, through to evening pool parties with friends.

Consider additions such as a swim-up bar in the pool and outdoor misting fans to keep you comfortable. Maintenance can be kept at a minimum with an array of pool cleaners on the market designed to do the hard work for you. Also consider pool covers to prevent evaporation and nasties entering the pool.

Extension

Creating a feature in the yard is one option, but take into consideration the alternative of adding to your house itself. It may sound expensive; however, if you have some handyman skills, it?s highly likely there is a kit home company that can provide what is essentially a flat-packed room. These companies will work through the planning and design with you and offer advice regarding council approval and building options.

If you have made the investment in some extra land, why not put it to good use and add some value to your property.

Source: http://www.urbancartography.com/home-improvements-big-spaces/

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New agreement lets Facebook and Zynga play the field, still shack up

New agreement lets Facebook and Zynga play the field, still shack up

It wasn't so long ago that Facebook and Zynga were making beautiful music (and money) together, but it seems that each is now looking for a bit of fresh air in the relationship, according to Reuters. A new agreement will give Zynga more freedom to offer games on its own website, while also allowing Facebook to develop its own -- though for now, the social network said it "was not in the business of building games and we have no plans to do so." For its part, Zynga now has the option of opting out of Facebook's payment mechanism and display ads, according to a recent filing by the Farmville maker. Both companies have seen their share of foibles, lately, but Facebook would perhaps be wise to not let its main dance partner too far out of sight -- Zynga still kicks in more than 15 percent of the now-public company's revenue.

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Via: Joystiq

Source: Reuters

Source: http://www.engadget.com/2012/11/30/new-agreement-lets-facebook-and-zynga-play-the-field/

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Schools Financial Credit Union Joins Coats for Kids Drop Off Box Photo Gallery Contest

These photos were submitted by?Christal Guo?with?Schools Financial Credit Union?as part of our Coats for Kids Drop Off Box photo gallery contest. Pictures are from the Roseville and?Calvine Pointe branches.

Here's the contact info for each of the branches:

Calvine Pointe Branch, 8848 Calvine Rd, Suite 110, Sacamento 95828
Roseville Branch, 1601 Douglas Blvd, Roseville 95661

Thank you?Christal for being part of the Coats for Kids campaign and for participating in this contest!

`````````````````````````
Want to have some fun, promote your organization and possibly win a prize, while you're helping us keep more than half a million families warm?

Just dress up your drop off box and email us 4 or more pictures of it to writer@news10.net.

When you do, we'll create a photo gallery article on News10 My Neighborhood. AND, if you send us text about your business, school or non-profit organization in that same email, we'll add that to the article.

THEN, we'll submit you into our random drawing and the winner will receive a $30 Target gift card.

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If you want to learn more about becoming a drop off box location, Click HERE to sign up!

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Source: http://natomas.news10.net/news/business/107837-schools-financial-credit-union-joins-coats-kids-drop-box-photo-gallery-contest

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Thursday, November 29, 2012

Atari celebrates 40 years of Pong with new, free iOS Pong game, custom portable Xbox 360

Atari celebrates 40 years of Pong with new, free iOS Pong game, sweet portable Xbox 360

Atari's celebrating 40 years of arcade classic Pong today by releasing ... another version of Pong. Pong World is being dubbed "the first-ever official new Pong game on iOS" (despite our search of the App Store dictating the contrary), but more importantly, it's totally free and it's already available on the iOS App Store (see gameplay below the break). The iPhone / iPad / iPod Touch game started life as one of many entries in Atari's "Pong Indie Developer Challenge," which pitted devs against each other for $50K and lead representation on the big four-zero celebration.

Should the free game not be enough for you, you could always vie for one of the crazy sweet portable Xbox 360s (seen above) on Atari's Facebook page. Why yes, that is a custom LCD screen attached to a modded Xbox 360, which also happens to resemble a classic Atari console. And yes, we agree, it is totally sweet.

Continue reading Atari celebrates 40 years of Pong with new, free iOS Pong game, custom portable Xbox 360

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Source: iOS App Store, Facebook


Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/VeVh2I8-MoE/

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The Full Monty: Mill Valley-Miege Football Preview, Part II: Will we see starters play all four quarters?

Image

A quick look at Miege:

The Stags are averaging 31.9 points per game compared to Mill Valley?s 52.3. Miege allows 20 points per game on defense. Mill Valley has limited opponents to single digits four times this year.

Miege?s four victories are against Turner (5-4), Blue Valley North (2-7), Gardner-Edgerton (6-3) and Harmon (0-9). Meanwhile, the Stags fell on hard times with a four-game skid earlier this year against Blue Valley Northwest (4-5), Blue Valley (5-4), Blue Valley Southwest (5-4) and Blue Valley West (7-2). The Stags have scored style points in victory, winning by an average margin of 34.75 points, a figure no doubt skewed by their Oct. 19 68-6 victory against the winless Harmon.

In defeat, the Stags have dropped four of five by a one-score margin, coming up an average of 6.8 points short. These two trends, taken together, produce the following stat: Bishop Miege is 0-4 in games decided by seven points or less. Meanwhile, Mill Valley has yet to play a game decided by seven points or less through its nine games?so, you?re guess is as good as mine.

Miege has fared slightly better on the road than at home, going 2-2. Mill Valley is undefeated at home at 5-0.

???

One of the Dispatch?s contributing writers, Charles Redfield, has seen his share of Johnson County football. Working at the Johnson County Sun for years and stringing for the Kansas City Star has allowed Redfield to take a look at some of the abovementioned teams in question. He weighed in recently with the following observations:

Not an easy draw for Mill Valley. Miege is not a 4-5 team. Their QB is good, but they don?t really have a great rushing attack. Cozart throws the long pass better than the short pass. The defense has given up a lot of points against good teams.

???

For the season, Windmiller has completed 60.3 percent of his passes for 1,955 yards and 28 touchdowns with seven interceptions. Windmiller is also one of three Jaguars to rush for more than 500 yards, carrying 78 times for 511 yards (6.55 per carry) and seven scores. In a 47-6 victory against Basehor-Linwood on Sept. 14, Windmiller rushed 20 times for 157 yards and four touchdowns.

Despite not finishing any of his team?s eight victories, Windmiller has thrown for a career-high 28 scores, up from 25 in 2011 and 21 in 2010. Windmiller has never thrown more than nine interceptions in one season.

Mill Valley?s rushing attack is led by a resurgent senior Kendall Short, who recovered from an early-season injury to rush for 521 yards on 77 carries (6.77 per carry) and eight touchdowns, while adding seven receptions for 191 yards and four touchdowns.

Here?s some trivia: The Jaguars? top rusher is freshman backup quarterback Logan Koch, who has spelled Windmiller in each of the Jaguars? blowouts. Koch leads the team with 535 yards on 68 carries (a team-high 7.87 yards per carry) and six touchdowns. Unless the Jaguars have a surprise formation on tap, however, we may not see much of Koch in the playoffs.

All season, Windmiller?s favorite targets have been L.J. Hatch (37/813/12) and Staton Rebeck (34/454/8). The duo have also done damage in special teams. Rebeck averages more than 26 yards per punt return, with a long of 88. Hatch, meanwhile, averages 44 yards per kickoff return with a long of 85. Rebeck has also taken sic kickoff returns, averaging more than 32 yards per return with a long of 53.

Defensively, Mill Valley has three players with 68 tackles or more: T.J. Phillips (88), Blake Miles (71) and Micah Clarke (68). The Jaguars have intercepted opponents 12 times this year and have recorded 11 fumble recoveries. Senior defensive lineman Tim Thomas leads Mill Valley with eight sacks.

What?s not on the stat sheet is the versatility of the Jaguars? offensive line, filling in for the injured Coleman McCann, who sat out the second half of the season. Adam Swearingen, Knute Holden and Evan Applegate have been among those to step up, but Swearingen got banged up against Schlagle last month.

Source: http://www.shawneedispatch.com/weblogs/full-monty/2012/nov/01/mill-valley-miege-football-preview-part-ii-will-we/

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Navy fires president, provost of grad school

WASHINGTON (AP) ? Navy Secretary Ray Mabus has fired the top two administrators of the Naval Postgraduate School in Monterey, Calif., for mismanagement and fostering an atmosphere of defying Navy rules and regulations.

The firings of the school's president and provost come after an investigation by the Navy's inspector general. It found that the president, Daniel Oliver, failed to comply with federal and naval regulations, circumvented federal hiring authorities and inappropriately accepted gifts from a private foundation that supports the school.

The investigation also found that the provost, Leonard Ferrari, did not comply with Navy regulations and accepted gifts from the foundation.

According to the IG report, Oliver arranged for an unidentified woman to be hired as a contractor so that she could be paid more money than the school could legitimately offer. The report said Oliver circumvented federal salary limits after the applicant turned down the school's initial salary offer of $162,000, with a recruitment bonus of $25,000, according to the IG report. The offer was the maximum allowed under federal salary caps at that time, in 2009.

The report said Oliver arranged for an existing school contractor ? Digital Consulting Services ? to hire the woman, for a salary of $275,000, which she accepted.

"We conclude President Oliver's conduct amounts to waste and gross mismanagement," the IG report said.

The report also said that Oliver solicited and accepted gifts from the foundation, including a gas grill and patio furniture for his home on the campus, in violation of Navy procedures. The IG also concluded that both Oliver and Ferrari authorized the foundation to repay themselves, faculty members and staff for expenses ? such as luncheons, dinners, small gifts, or wine for a reception ? that they knew they could not otherwise use school funding to buy.

Oliver, a retired vice admiral and naval aviator, has held the job since April 2007, and Ferrari has been in place since July 2006.

Mabus has appointed Rear Adm. Jan Tighe to serve as interim school president, and O. Douglas Moses, the current vice provost of academic affairs, will serves as the acting provost. Mabus also has created a working group that will implement the recommendations in the IG report.

A message seeking comment from the school was not immediately returned.

Oliver and Ferrari could not be located for comment.

___

Online:

IG Report: http://www.ig.navy.mil/Divisions/Legal/FOIA%20Reading%20Room.htm

Source: http://news.yahoo.com/navy-fires-president-provost-grad-school-235704867.html

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Wednesday, November 28, 2012

East Asia faces unique challenges, opportunities for stem cell innovation

ScienceDaily (Nov. 27, 2012) ? Tension is the theme running through the new consensus statement issued by the Hinxton Group, an international working group on stem cell research and regulation. Specifically, tension between intellectual property policies and scientific norms of free exchange, but also between eastern and western cultures, national and international interests, and privatized vs. nationalized health care systems.

The consensus, titled Statement on Data and Materials Sharing and Intellectual Property in Pluripotent Stem Cell Science in Japan and China, was released on the Hinxton Group's website on November 19, 2012.

"China and Japan are among the world's leading nations in stem cell research, but because of challenges distinct from western nations, they are dramatically underrepresented in terms of patents and licensing," says Debra Mathews, PhD, MA, assistant director of Science Programs at the Johns Hopkins Berman Institute of Bioethics and a founding member of the Hinxton Group. Mathews was one of 22 co-signers of the consensus statement.

"We thought it was crucial, with the science advancing incredibly rapidly, and as intellectual property policies evolve in East Asia, to examine our 2010 global recommendations for proprietary issues in stem cell research in that regional context," Mathews says.

Strengthening national stem cell innovation was the top goal articulated in Kobe, the statement says. Whereas in the West there is a robust and mature infrastructure for encouraging and supporting the development of intellectual property rights such as patents, East Asian nations like China and Japan have comparatively less well-developed, younger systems, the group observes. While this can make it more difficult to bring new inventions to international markets, the statement says, the opportunities created by the regional environment in Japan and China provide valuable lessons for the global development of this field.

"For example, as noted in the statement, Japan and China each have a large and highly qualified scientific workforce, paired with substantial national investment in stem cell research," says Mathews. "This combination of factors means that both countries are well-situated to take the kinds of collective action that will be required to move the field forward efficiently and translate basic science discoveries into products and therapies."

An area where Japan and China exercise strong state control to the possible benefit of stem cell-based invention is their national health care systems, the statement notes. In the West, strong intellectual property rights have encouraged the "development of stand-alone blockbuster products," the group says, whereas the national health systems in East Asia may allow patients access to more individualized, innovative treatments. This, the group posits, could be a model for stem cell-based therapies.

"Innovation in China and Japan occurs in the context of national commitments to public health, and as a practical matter that should make access to cell-based therapies more equitable," Mathews says.

The statement also notes the significant cultural differences that contribute to challenges -- and opportunities -- with intellectual property policy, practice and stem cell research in the region. The group notes that Japan and China are "markedly less litigious" than western nations, and recognition for scientific work and publication priority are highly valued. "Secrecy appears to be a relatively more common mode of protecting researchers' raw [intellectual property rights], as opposed to more formalized legal systems of protection, such as patenting," the statement says. In light of this, an appropriate incentive to sharing data and materials among scientists in the region would be the protection of their interests and rights, perhaps through a grace or priority period, the group says, during which the data is public but the original scientists have exclusive rights to publish.

The statement also discusses the challenges of sharing data and materials internationally, noting an "underlying tension between national and international interests." In China, for example, samples donated by citizens are considered intellectual property of the state and are governed by strict polices that create roadblocks to international sharing and access. Such policies, varying country by country, may present significant challenges to the Hinxton Group's goal of creating an internationally coordinated stem cell bank, the statement says.

"There will always be tensions between national and international and between public and private," as far as innovation and the protection of that innovation, the group says. "Within the biomedical sciences, the key is to strike a balance that both promotes innovation and improves global health," the statement concludes.

Consensus Statement: www.hinxtongroup.org/consensus_hg12_final.pdf

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/hDntrw8GZ-4/121127154211.htm

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Jeb Bush's reputation as education reformer gets a second look ...

Steve Cannon / AP file

Fla. Gov. Jeb Bush looks at a chart showing Florida's Comprehensive Assessment Test results in Tallahassee on May 10, 2004.

By Stephanie SimonReuters

Former Florida Gov. Jeb Bush soared to rock star status in the education world on the strength of a chart.

A simple graph, it tracked fourth-grade reading scores. In 1998, when Bush was elected governor, Florida kids scored far below the national average. By the end of his second term, in 2007, they were far ahead, with especially impressive gains for low-income and minority students.

Those results earned Bush bipartisan acclaim. As he convenes a star-studded policy summit this week in Washington, he is widely regarded as one of the most influential education reformers in the U.S. Elements of his agenda have been adopted in 36 states, from Maine to Mississippi, North Carolina to New Mexico.

Many of his admirers cite Bush's success in Florida as reason enough to get behind him.

But a close examination raises questions about the depth and durability of the gains in Florida. After the dramatic jump of the Bush years, Florida test scores edged up in 2009 and then dropped, with low-income students falling further behind. State data shows huge numbers of high school graduates still needing remedial help in math and reading.


And some of the policies Bush now pushes, such as vouchers and mandatory online classes, have no clear links to the test-score bump in Florida. Bush has been particularly vigorous about promoting online education, urging states to adopt policies written with input from companies that stand to profit from expanded cyber-schooling.

Many of those companies also donate to Bush's Foundation for Excellence in Education, which has raised $19 million in recent years to promote his agenda nationwide.

Sherman Dorn, a professor of education at the University of South Florida, says some of Bush's policies as governor, such as an intense focus on teaching reading, made a real difference to Florida students.

?"It's pretty clear Governor Bush should get credit for giving a damn," he said. But by teaming with for-profit corporations to push cyber-schools, which have produced dismally low test scores in many states, Bush is "throwing away whatever credibility he had coming out of Florida," Dorn said.

Bush's allies disagree. For them, the former governor -- widely considered a top contender for the 2016 Republican presidential nomination -- is a visionary striving to build on his record of success.

"I've been very impressed with the thoughtfulness of his policies," said Joel Klein, who ran New York City schools for eight years and now heads News Corp's education division, Amplify, which donates to the Bush foundation.

Klein and officials at several other education companies that support Bush's foundation say they do so not for their own financial interest but to promote a broad policy debate.

Any implication "that corporate donors give to us for us to advance their agenda" is simply false, said Patricia Levesque, the foundation's executive director.

The Florida formula
Bush, who declined to comment for this story, says often that he has one abiding goal: to give all students the chance to reach their "God-given potential."

His "Florida formula" rests on the principles of increasing accountability and expanding parental choice. Among its tenets:

* Grade schools on an A-to-F scale, based mostly on student scores and growth on standardized tests. Give students in poorly ranked schools vouchers to attend private and religious schools.

* Hold back 8-year-olds who can't pass a state reading test rather than promote them to fourth grade.

* Expand access to online classes and charter schools, which are publicly funded but privately managed, sometimes for profit.

In Florida, Bush paired his tough-love measures with generous support. Schools that improved their grade or got an "A" received extra funding. Teachers got bonuses for successes like getting more kids to pass Advanced Placement tests. And students required to repeat third grade got intensive help at free summer reading camps.

States adopting the policies now, in a time of austerity, tend to leave out the costly support systems. That has stirred protests from school superintendents, school board members, teachers unions and parents who see the policies as punitive, humiliating and too narrowly focused on a single test as a measure of success.

Voters have spoken loudly, too. In this month's election, overwhelmingly Republican electorates overturned Bush-style reforms in Idaho and South Dakota and ousted the Indiana state schools chief, who had enacted much of the Florida formula.

In Florida, meanwhile, the durability of the Bush-era gains has come into question.

NBC News' Education Nation case studies

High school graduation rates rose during Bush's tenure but remain substantially lower than in other large and diverse states, including California, New York and Ohio, according to new federal data. Students' average score on the ACT college entrance exam has not improved and remains well below states such as Missouri and Ohio, where a comparable percentage of students take the test.

Florida's scores on the National Assessment of Educational Progress, widely considered the most reliable metric, dropped on all four key tests last year -- ?fourth- and eighth-grade reading and math. On all four tests, low-income students fell further behind their wealthier peers.

Jaryn Emhof, a spokeswoman for the Bush foundation, said the slipping scores are an indication that "schools were getting complacent" and need to be pushed with higher standards.

Opponents contend Bush's reforms never deserved much credit for the gains in the first place.

Other factors were at play, they argue. Florida voters passed a constitutional amendment to limit class size in 2002, for instance. And Bush's tenure coincided with soaring property tax receipts, thanks to the housing boom, which led to more local funding for schools. Per-pupil spending in Florida jumped 22 percent from 2001 to 2007, after accounting for inflation. It has since fallen sharply.

"There's this single-minded notion that only the program has supported yield improvements," said Ruth Melton, director of legislative relations for the Florida School Boards Association. "There's more to this than meets the eye."

Some recent research has cast doubt on the long-term effectiveness of the Bush policies.

A Harvard education research group reported this summer that Florida students who were held back in third grade notched a big boost in test scores initially, but the effects faded to insignificance before they entered high school. And annual studies commissioned by the state have found no evidence that low-income students who receive vouchers to attend private schools do any better at reading or math than their peers.

As for Florida's charter schools, a recent report found their students consistently outscore kids in traditional schools on state tests. The charters, however, serve fewer poor and special-needs students and fewer students still learning English.

Meanwhile, researchers have found that other states, such as Massachusetts, have boosted achievement without Florida-style reforms, using more old-fashioned remedies such as increasing spending and imposing rigorous curricular standards.

After an exhaustive study of state-by-state academic gains, the Harvard researchers concluded in a July report that "the connection between reforms and gains ... thus far is only anecdotal, not definitive."

Emhof, the Bush foundation spokeswoman, said that while "there is no silver bullet" to improve schools, the Florida formula "is the path with the most proven results." The state's size and diversity mean "if something works in Florida, it can work anywhere," she said.

Meet and greet
Indeed, the Bush foundation touts the Florida test gains as "perhaps the greatest public policy success story of the past decade" and aggressively presses its formula on other states.

Hundreds of emails obtained under a public records request by the nonprofit advocacy group In the Public Interest, which opposes privatization of schools, show the foundation working closely with allies in Maine, New Mexico, Florida and elsewhere to craft public policy.

Foundation employees write legislation and edit proposed bills line by line, then send in experts to testify on their behalf, the emails show.

The Bush foundation also funds trips and events to introduce Bush's donors to policy makers. At last year's national summit in San Francisco, the foundation set aside two hours for several state superintendents of education, dubbed "Chiefs for Change," to meet the foundation's sponsors.

In an email forwarded to Executive Director Levesque, an official from Apple Inc. also requested access to the chiefs to tout the company's products.

"This is a great opportunity. ... But there are a dozen other companies that want access," Levesque responded. She couldn't accommodate Apple, she wrote, unless the chiefs first found time to meet with "all the other companies including those actually funding" the Chiefs for Change network.

Apple declined to comment.

Bush foundation donors include family philanthropies, such as those established by Microsoft founder Bill Gates and New York City Mayor Michael Bloomberg. Corporate donors include Connections Education, a division of global publishing giant Pearson; Amplify, the education division of Rupert Murdoch's News Corp.; and K12, a publicly traded company that runs online schools.

Many of these donors sit on a Digital Learning Council that helped draft the Bush foundation's policy agenda. Key planks call for states to require online course work in high school and to lift restrictions that hinder cyber-school growth, such as limits on class size.

Studies in several states including Pennsylvania and Colorado have found that online students fare far worse than their peers in reading and math. Bush has said bad programs should be shut down, but he believes online schools have great potential to offer personalized, self-paced education.

"This is not about our commercial success," said Sari Factor, chief executive officer of E2020 Inc., which develops online curricula and recently signed up as a foundation sponsor. "We're focused on what's right for kids."

Still, Factor acknowledged that E2020 has "absolutely" benefited from Bush's advocacy.

In particular, Bush often talks up an Arizona charter school called Carpe Diem, which uses the E2020 online curriculum, employing just four teachers for 225 students because the kids do so much work online. Bush has flown policy makers from across the country to admire the school's innovation and cost cutting. That has brought more clients to E2020, Factor said.

Arizona data shows Carpe Diem test scores have fallen sharply over the past two years, a drop founder Rick Ogston attributes to a new curriculum and the sudden death of the principal.

That has not slowed its momentum; after visiting Carpe Diem on a trip paid for by the Bush foundation, Indiana officials urged Ogston to apply to open a branch there. The head of the state charter school board, Claire Fiddian-Green, says the school's "fairly strong track record" impressed her despite the recent slip in test scores. The new Carpe Diem campus in Indianapolis opened this fall.

Ogston said he and other charter and online school operators count on Bush's foundation to remove obstacles to their growth, such as state laws that require students to put in time in a physical classroom.

"We come to them to say, 'These policies are in the way, and it would be great if you could change them,'" Ogston said. "That's what they do better than anyone."?

More from Open Channel:

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Source: http://openchannel.nbcnews.com/_news/2012/11/27/15485391-jeb-bushs-reputation-as-education-reformer-gets-a-second-look

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Amid bitter leadership row, French conservatives tap Cop

Jean-Fran?ois Cop? today was named the winner of the conservative UMP party's recount. But rival Fran?ois Fillon begs to differ.

By Bastien Inzaurralde,?Correspondent / November 26, 2012

In this file photo, former French Prime Minister Fran?ois Fillon, left, and French conservative party UMP Secretary General Jean-Fran?ois Cop? pose for photographers before a televised debate last month. The two men have been locked in a contentious fight over leadership of the UMP.

Christophe Ena/AP/File

Enlarge

An internal committee investigating the contentious Nov. 18 election for leadership of France's right-wing opposition UMP party has declared a winner, but the struggle between two prominent French conservatives over the UMP's top spot looks set to continue, likely in court.

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The party's internal investigation began last week after initial results showed Jean-Fran?ois Cop? with only a 98-vote victory over Fran?ois Fillon. Today, the committee declared Mr. Cop? the UMP's new leader. But while Cop? called for the party to choose "forgiveness instead of division," Mr. Fillon rejected the recount as "illegal."

Fillon was prime minister during former President Nicolas Sarkozy?s tenure and is considered more moderate than Cop?, the current party leader who held a position equivalent to a US House majority leader until June, when the Socialist party and its allies won France's parliamentary elections.

What started as a neck-and-neck election eight days ago between Cop? and Fillon has quickly escalated into a public political war to succeed President Sarkozy as right-wing leader, with both men fiercely criticizing each other and accusing one another of cheating.

Both Fillon and Cop? claimed victory in the election on Nov. 18. But the next day, a UMP commission tasked with overseeing the election declared Cop? the winner by a mere 98 votes, and the tension between the two sides has grown steadily since.

On Wednesday, Fillon?s camp said that votes from three overseas territories hadn?t been counted and claimed that adding them to the vote tally would mean victory for Fillon. In today's announcement, the investigating committee put Cop? ahead by 952 votes after the recount.

An inheritance from Sarkozy?

St?phane Roz?s, a political analyst and the president of Cap, a communications consulting company, says the turmoil within the UMP stems in part from the void left by Mr. Sarkozy after he lost this year?s presidential election to Fran?ois Hollande.

?Nicolas Sarkozy didn?t leave anything that could allow the right wing to structure itself around a body of doctrine, because everything was organized around his person,? Mr. Roz?s says. ?The only thing that remained is a radicalization of the UMP that took [the party] further away from right-wing sympathizers.?

An editorial in the weekend edition of France?s most prestigious newspaper Le Monde argued that Sarkozy was to blame for the current crisis because he took the party too far to the right during the last presidential campaign. At the same time, Le Monde wrote, the UMP has not been able to move on since Sarkozy left power, nor has it engaged in any kind of soul-searching.

?Nicolas Sarkozy is not the big winner of this fratricidal war,? the editorial read. ?He is the cause of it.?

Trading barbs

Regardless of the cause, the debate over the election has led to a toxic atmosphere within the party, with Fillon and Cop? trading barbs publicly.

"The behavior of Fran?ois Fillon, it?s the story of an inelegant loser who now comes to give lessons of morality without applying them to himself,? Cop? told Europe 1 radio on Thursday.

The following day, Fillon had a few words for Cop?. ?I measure all the damages from this crisis, but at the same I want to say that a political party is not a mafia,? Fillon told RTL radio. ?A political party, it?s not a place where you can bury cases, refuse to tell the truth.?

On Sunday morning, Fillon?s team refused to recognize the UMP commission examining allegations of fraud as legitimate. In the evening, mediation between Cop? and Fillon by former French Prime Minister Alain Jupp?, who is considered the party?s moral gatekeeper, proved unsuccessful. The mediation attempt appeared to be a last resort and its failure was met by angry reactions on both sides.

Fillon took to Twitter after the meeting to blame Cop? for the failed talks and announced he would go to court. He tweeted, ?I will go to court to restore the truth of the results and give the party base its voice back.?

Agence France-Presse, relying on anonymous sources, reported that Sarkozy advised Fillon not to go to court when the two met for lunch on Monday. Sarkozy also said it would be better that a new election be held, according to Agence France-Presse.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/ovnmVR3PkOE/Amid-bitter-leadership-row-French-conservatives-tap-Cope

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Tuesday, November 27, 2012

Apple's Eddy Cue reportedly fires Richard Williamson, who oversaw the iOS 6 Maps team

Apple's Eddy Cue reportedly fires Richard Williamson, who oversaw the team responsible for iOS 6 Maps

We aren't apt to ever hear this in official fashion, but Bloomberg has it on good authority that Apple's newly-promoted Eddy Cue has just fired the guy who was unfortunately leading the Maps team at the time of iOS 6's release. If you'll recall, Cue was placed in charge of both Siri and Maps during an executive shakeup back in October, and it seems that he's clearing the runway in order to make things better in the months to come. The report also mentions that Cue is "seeking advice from outside mapping-technology experts and prodding digital maps provider TomTom to fix landmark and navigation data it shares with Apple." It's assumed that the goal here is to install a new leadership team within the Maps group, but it's unclear if it'll happen prior to Google's own standalone iOS app becoming available. For those curious as to why such a drastic move had to be made, head over to Apple's Cupertino campus and use iOS 6's Maps app to search for "convenience store." Evidently, the closest one is some 1.5 hours north in San Francisco. True story.

Filed under: ,

Comments

Via: 9to5Mac

Source: Bloomberg


Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/YXPJOze6h80/

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Selby's Food Corner: Pasta de Waraku - Indonesian Feast with a ...

Pasta de Waraku is one of my favorite places for having fusion Japanese pasta and pizza. I was pretty?intrigued? when I received an invitation from Pasta de Waraku to try their?new special menu - Indonesian Feast with a Twist, which they claimed as a unique twist to Japanese dishes with the richness of Indonesian taste that will tantalize the buds.

Together with some other food bloggers and media, we tried the below dishes:

Appetizer

Korokoro Tofu - Rp. 25.000

Deep Fried Seasoned Tofu

Calamari - Rp. 35.000

Fried Squid Rings

Edamame - Rp. 10.000

Soybean Pods

Pizza

Salmon Pizza with Curry Sauce - Rp. 50.000 (medium), Rp. 65.000 (large)

Thin crust Pasta de Waraku pizza topped with baked salmon in curry sauce sprinkled with slice of chili, cucumber and onion. As usual, I enjoyed the thin crispy crust though I wish the topping could taste richer.

Pasta

?Beef Spaghetti with Rendang Sauce - Rp. 58.000

Not your average beef spaghetti, instead of standard bolognese sauce, they use rendang sauce which is famous known for its richness flavors and also with mince beef and quail eggs. Good thing that the rendang was not as spicy as I expected.

Fried Oxtail ala Java - Rp. 65.000

Spaghetti aglio e olio cooked with Wafu sauce, completed with fried oxtail and red bell pepper. Frankly speaking, I was not really keen to see the red chili paste on the top of this spaghetti aglio e olio.

?Traditional Fried rice with Angus beef - Rp. 65.000

The authentic taste of Indonesian traditional fried rice cooked with salted fish and shrimp paste. For the combination with Japanese dishes , use Angus beef in Teriyaki sauce and also completing with egg on top. The Angus beef was nice. The fried rice was tasty but too spicy because of the chili seeds.

Indonesian Grilled Ribs Spaghetti - Rp. 65.000

Spaghetti Aglio Olio cooked with Wafu sauce, completed with grilled ribs and fried white onion. Also served with 2 types of chili paste: red chili and green chili. If you are a chili lover, you will definitely love this dish but for me, after I ate a spoon of it, my lips and?tongue?felt like they were on fire :(

Strawberry Cheesecake Milkshake - Rp. ?28.000

I need milk to cool down of my lips and?tongue.?

Grilled Chicken Spaghetti- Rp. 58.000

Signature?Spaghetti aglio Olio cooked with Wafu sauce, completed with juicy grilled chicken covered chili paste on top.?I didn't try this one because I still felt the burning sensation on my lips and?tongue :(

Dessert

?Baby Hanito - Rp. 32.000
Juicy Fruits (left)

Banana Crumble (middle)

Candyland (right)
The name "Baby Hanito" really represents the size of it. It's a 6 cubes of honey toast with toppings. For the toppings, I still prefer the ones that are put on those?original Hanito?like Hanito Macha Red Bean and Hanito Earthquake.

All prices are subjected to service charge and PB1 tax.

Current currency: 1 USD = Rp. 9.600

At the end of this food tasting, it was hard for me to enjoy the food because I'm not a chili person. There are so many Indonesian food without chili. Why all these pastas and pizza need to have chili? Does food with chili really represent Indonesian food? I understand a lot of people love chili but there are people and also children who can not tolerate it. I guess it would be wise to add other non chili pasta and pizza with Indonesian twist to the menu.


Location
Pasta de Waraku
Pondok Indah mall 2
Restaurant Row, level 3 No. 343A
Jl. Met5ro POndok Indah Blok 3B
Jakarta Selatan
Tel: 75920608

Related posts:
Pasta de Waraku - Jakarta
Pasta de Waraku (Food Tasting Panel)

Source: http://selbyfood.blogspot.com/2012/11/pasta-de-waraku-indonesian-feast-with.html

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Obvious-Incubated Lift Lands $2.5M From Spark Capital, SV Angel To Help You Build Good Habits

Screen shot 2012-11-27 at 6.34.24 AMAfter nearly a year in development, Lift launched its first mobile product in August behind an ambitious goal: Boost human potential by helping people achieve their goals. It almost sounds New Age-y, but co-founders Tony Stubblebine and Jon Crosby are serious about doing their part to change the world and support personal achievement. The founders aren't alone. From the get-go, Lift has been incubated and seed-funded by Obvious Corp., the hybrid accelerator created by Twitter co-founders Biz Stone, Evan Williams and early Twitter VP Jason Goldman. And now Lift is adding more believers to its support network, announcing today that it has closed a $2.5 million series A round, led by Bijan Sabet of Spark Capital, who joined the co-founders and Ev Williams on Lift's board of directors.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/baGFQOP0fhY/

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Health, Fitness and Excerise for Life ? Blog Archive ...


Learn how to use the recumbent bike, which is a great workout for people with back trouble, in this free exercise video tutorial on using gym equipment. Expert: David Feraco Bio: Dave Feraco is a certified personal trainer at MG Fitness in Medford, MA. Filmmaker: Paul Ferguson

F3 Cross Training Gym Tour. F3 Cross Training is located in Houston TX and is a fully functional fitness and combative studio. 90% of our equipment is homemade exercise equipment. www.f3crosstraining.com
Video Rating: 4 / 5

Source: http://www.mrgymhealth.com/?p=175

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Monday, November 26, 2012

Powerball Numbers Find No Winner, Jackpot Reaches Record High


WASHINGTON, Nov 25 (Reuters) - The top prize in the Powerball lottery will reach a record $425 million after no one won Saturday's drawing, a lottery official said on Sunday.
Iowa Lottery spokeswoman Mary Neubauer said the jackpot was $325 million for the drawing late on Saturday. Powerball has not had a winner for two months.
The $425 million record jackpot could be raised before Wednesday's drawing since big payouts tend to spur sales, Neubauer said.
"We'll watch sales to see if an adjustment upwards needs to be made," she said. The cash payout will be a record $278.3 million.
The previous top Powerball prize was $365 million, won in 2006 by ConAgra slaughterhouse workers in Nebraska. The Powerball lottery is held in 42 states, the District of Columbia and the U.S. Virgin Islands.
In March, three winning tickets shared the largest U.S. lottery jackpot, the $656 million Mega Millions drawing
The winning Powerball numbers for Saturday were 22-32-37-44-50, and the Powerball was 34.
(Reporting by Ian Simpson; Editing by Bill Trott)

Also on HuffPost:

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Source: http://www.huffingtonpost.com/2012/11/25/powerball-numbers-jackpot-425-million_n_2188039.html

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Black Friday sales online top $1 billion for first time: comScore

SAN FRANCISCO (Reuters) - Black Friday retail sales online this year topped $1 billion for the first time ever as more consumers used the Internet do their early holiday shopping, comScore Inc said on Sunday.

Online sales jumped 26 percent on Black Friday to $1.04 billion from sales of $816 million on the corresponding day last year, according to comScore data.

Amazon.com was the most-visited retail website on Black Friday, and it also posted the highest year-over-year visitor growth rate among the top five retailers. Wal-Mart Stores Inc's website was second, followed by sites run by Best Buy Co., Target Corp. and Apple Inc, comScore noted.

Digital content and subscriptions, including e-books, digital music and video, was the fastest-growing retail category online, with sales up 29 percent versus Black Friday last year, according to comScore data.

E-commerce accounts for less than 10 percent of consumer spending in the United States. However, it is growing much faster than bricks-and-mortar retail as shoppers are lured by low prices, convenience, faster shipping and wide selection.

ShopperTrak, which counts foot traffic in physical retail stores, estimated Black Friday sales at $11.2 billion, down 1.8 percent from the same day last year.

"Online has been around 9 percent of total holiday sales, but it could breach 10 percent for the first time this season," said Scot Wingo, chief executive of ChannelAdvisor, which helps merchants sell more on websites, including Amazon.com and eBay.com.

ComScore expects online retail spending to rise 17 percent to $43.4 billion through the whole holiday season. That is above the 15 percent increase last season and ahead of the retail industry's expectation for a 4.1 percent increase in overall spending this holiday.

CYBER MONDAY OUTLOOK

It's not clear yet whether strong Black Friday sales online will weaken growth on Cyber Monday, which has been the biggest e-commerce day in the United States in recent years.

"Cyber Monday will be a big day, but not as much of a big day as it has been in the past," said Mia Shernoff, executive vice president for Chase Paymentech, a payment-processing unit of J.P. Morgan Chase & Co.. "Faster broadband Internet connections in the office used to drive this. But now many consumers have faster connections at home and smart phones and tablets - they don't have to wait."

ComScore Chairman Gian Fulgoni said Cyber Monday online sales may reach $1.5 billion this year. That would be up 20 percent from the corresponding day last year - slower year-over-year growth than Thanksgiving and Black Friday.

More than 129 million Americans plan to shop online on Cyber Monday, up from almost 123 million on the same day last year, according to a survey conducted in recent days for the National Retail Federation.

The group also expects 85 percent of retailers to have a special promotion for Cyber Monday.

Amazon, the world's largest Internet retailer, will launch Cyber Monday deals at midnight on Sunday. The company is planning a limited time Cyber Monday promotion for its 7 inch Kindle Fire tablet, offering it at $129 instead of the regular $159, a spokesman said on Sunday.

MOBILE SHOPPING GROWTH

A big source of online shopping growth this holiday season has come from increased use of smart phones, which let people buy online even when they are in physical stores, and by tablet computers, which have spurred more online shopping in the evenings, Wingo and others said.

Mobile devices accounted for 26 percent of visits to retail websites and 16 percent of purchases on Black Friday. That was up from 18.1 percent and 10.3 percent, respectively, on the same day last year, according to International Business Machines, which analyzes online traffic and transactions from 500 U.S. retailers.

More than 20 million shoppers plan to use mobile devices on Cyber Monday, up from 17.8 million a year ago, the NRF said.

AMAZON AND eBAY

Amazon and eBay benefit from increased use of mobile devices for shopping because they are consistently the top two online retail destinations for mobile users, ChannelAdvisor's Wingo said.

Amazon.com was the most visited retail website on Black Friday, with more than 28 million visits, according to Hitwise.

Worth noting: eBay runs one of the largest online marketplaces, rather than being a retailer, so its online traffic was not reported by Hitwise. However, eBay said the volume of mobile transactions on its marketplace jumped 153 percent on Black Friday from a year earlier.

ChannelAdvisor clients' same-store sales on Amazon.com shot up 43 percent on Saturday, compared with a year earlier. Last year's year-over-year growth was 49 percent on the Saturday following Black Friday.

Client same-store sales on eBay's marketplace rose 36 percent on Saturday, compared with a year earlier. Last year's year-over-year growth was 12 percent, according to ChannelAdvisor.

PRICE PRESSURE

While mobile devices may be good for sales, they may not be so good for retail profit margins. Smart phones give shoppers real-time access to product prices online, potentially exacerbating the usual holiday discounting and price wars.

Black Friday online transactions jumped almost 30 percent, but the average ticket price was down more than 11 percent, according to Chase Paymentech, which reports data from its 50 largest e-commerce merchant clients.

"It's driving prices down," Shernoff said. "Consumers are checking prices in stores and showing the retailer, and the retailer will succumb to the lowest price online so they don't lose the consumer."

(Reporting By Alistair Barr; Editing by Theodore d'Afflisio and Jan Paschal)

Source: http://news.yahoo.com/black-friday-sales-online-top-1-billion-first-165326723--sector.html

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Imaging shows some brains compensate after traumatic injury

Imaging shows some brains compensate after traumatic injury [ Back to EurekAlert! ] Public release date: 26-Nov-2012
[ | E-mail | Share Share ]

Contact: Linda Brooks
lbrooks@rsna.org
630-590-7762
Radiological Society of North America

CHICAGO Using a special magnetic resonance imaging (MRI) technique to image patients with mild traumatic brain injury (MTBI), researchers have identified a biomarker that may predict which patients will do well over the long term, according to a study presented today at the annual meeting of the Radiological Society of North America (RSNA).

The results of the study showed that in some patients the brain may have changed to compensate for the damage caused by the injury.

"This finding has huge potential implications for preventing and repairing the damage that accompanies traumatic brain injury," said Michael Lipton, M.D., Ph.D., associate director of the Gruss Magnetic Resonance Research Center at the Albert Einstein College of Medicine and medical director of MRI at the Montefiore Medical Center, Bronx, N.Y.

According to the Centers for Disease Control and Prevention, each year in the U.S. 1.7 million people sustain traumatic brain injuries. MTBI, or concussion, accounts for at least 75 percent of all traumatic brain injuries. Following a concussion, some patients experience a brief loss of consciousness. Other symptoms include headache, dizziness, memory loss, attention deficit, depression and anxiety. Some of these conditions may persist for months or even years in as many as 30 percent of patients.

Dr. Lipton and colleagues set out to determine the post-concussion symptoms and health-related quality of life for a group of patients with MTBI one year post-injury. The researchers recruited 17 patients with MTBI from the Emergency Department of Montefiore Medical Center. Within two weeks of their injury, the patients underwent diffusion tensor imaging (DTI), which measures the direction of movement of water molecules within and along axons, which comprise the bundles of nerve fibers in the brain's white matter.

"In a traumatic brain injury, it's not one specific area that is affected but multiple areas of the brain connected with axons," Dr. Lipton said.

Using DTI, the researchers measured the uniformity of water flow (called fractional anisotropy or FA) throughout the brain, pinpointing areas with low FA, which are indicative of axonal injury, and areas with abnormally high FA, as compared to healthy brains.

"Abnormally low FA within white matter has been associated with cognitive impairment in patients with TBI," Dr. Lipton said. "We believe that high FA is evidence not of axonal injury, but of brain changes that are occurring in response to the trauma."

One year after their brain injury, the patients completed two standard questionnaires to assess their post-concussion symptoms and evaluate their health status and quality of life.

Comparing the DTI data to the patient questionnaires, the researchers found that the presence of abnormally high FA was a predictor of fewer post-concussion symptoms and higher functioning. The results suggest that in patients who exhibit areas of high FA on DTI, the brain may be actively compensating for its injuries.

"These results offer us a new opportunity for treatment by finding ways to enhance the brain's compensatory mechanisms." Dr. Lipton said.

###

Coauthors are Sara B. Rosenbaum, B.A., Namhee Kim, Ph.D., Tova M. Gardin, B.A., Richard B. Lipton, M.D., and Molly E. Zimmerman, Ph.D.

Note: Copies of RSNA 2012 news releases and electronic images will be available online at RSNA.org/press12 beginning Monday, Nov. 26.

RSNA is an association of more than 50,000 radiologists, radiation oncologists, medical physicists and related scientists, promoting excellence in patient care and health care delivery through education, research and technologic innovation. The Society is based in Oak Brook, Ill.

Editor's note: The data in these releases may differ from those in the published abstract and those actually presented at the meeting, as researchers continue to update their data right up until the meeting. To ensure you are using the most up-to-date information, please call the RSNA Newsroom at 1-312-949-3233.

For patient-friendly information on MRI of the brain, visit RadiologyInfo.org.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Imaging shows some brains compensate after traumatic injury [ Back to EurekAlert! ] Public release date: 26-Nov-2012
[ | E-mail | Share Share ]

Contact: Linda Brooks
lbrooks@rsna.org
630-590-7762
Radiological Society of North America

CHICAGO Using a special magnetic resonance imaging (MRI) technique to image patients with mild traumatic brain injury (MTBI), researchers have identified a biomarker that may predict which patients will do well over the long term, according to a study presented today at the annual meeting of the Radiological Society of North America (RSNA).

The results of the study showed that in some patients the brain may have changed to compensate for the damage caused by the injury.

"This finding has huge potential implications for preventing and repairing the damage that accompanies traumatic brain injury," said Michael Lipton, M.D., Ph.D., associate director of the Gruss Magnetic Resonance Research Center at the Albert Einstein College of Medicine and medical director of MRI at the Montefiore Medical Center, Bronx, N.Y.

According to the Centers for Disease Control and Prevention, each year in the U.S. 1.7 million people sustain traumatic brain injuries. MTBI, or concussion, accounts for at least 75 percent of all traumatic brain injuries. Following a concussion, some patients experience a brief loss of consciousness. Other symptoms include headache, dizziness, memory loss, attention deficit, depression and anxiety. Some of these conditions may persist for months or even years in as many as 30 percent of patients.

Dr. Lipton and colleagues set out to determine the post-concussion symptoms and health-related quality of life for a group of patients with MTBI one year post-injury. The researchers recruited 17 patients with MTBI from the Emergency Department of Montefiore Medical Center. Within two weeks of their injury, the patients underwent diffusion tensor imaging (DTI), which measures the direction of movement of water molecules within and along axons, which comprise the bundles of nerve fibers in the brain's white matter.

"In a traumatic brain injury, it's not one specific area that is affected but multiple areas of the brain connected with axons," Dr. Lipton said.

Using DTI, the researchers measured the uniformity of water flow (called fractional anisotropy or FA) throughout the brain, pinpointing areas with low FA, which are indicative of axonal injury, and areas with abnormally high FA, as compared to healthy brains.

"Abnormally low FA within white matter has been associated with cognitive impairment in patients with TBI," Dr. Lipton said. "We believe that high FA is evidence not of axonal injury, but of brain changes that are occurring in response to the trauma."

One year after their brain injury, the patients completed two standard questionnaires to assess their post-concussion symptoms and evaluate their health status and quality of life.

Comparing the DTI data to the patient questionnaires, the researchers found that the presence of abnormally high FA was a predictor of fewer post-concussion symptoms and higher functioning. The results suggest that in patients who exhibit areas of high FA on DTI, the brain may be actively compensating for its injuries.

"These results offer us a new opportunity for treatment by finding ways to enhance the brain's compensatory mechanisms." Dr. Lipton said.

###

Coauthors are Sara B. Rosenbaum, B.A., Namhee Kim, Ph.D., Tova M. Gardin, B.A., Richard B. Lipton, M.D., and Molly E. Zimmerman, Ph.D.

Note: Copies of RSNA 2012 news releases and electronic images will be available online at RSNA.org/press12 beginning Monday, Nov. 26.

RSNA is an association of more than 50,000 radiologists, radiation oncologists, medical physicists and related scientists, promoting excellence in patient care and health care delivery through education, research and technologic innovation. The Society is based in Oak Brook, Ill.

Editor's note: The data in these releases may differ from those in the published abstract and those actually presented at the meeting, as researchers continue to update their data right up until the meeting. To ensure you are using the most up-to-date information, please call the RSNA Newsroom at 1-312-949-3233.

For patient-friendly information on MRI of the brain, visit RadiologyInfo.org.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2012-11/rson-iss111612.php

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Sunday, November 25, 2012

Patient's own immune cells may blunt viral therapy for brain cancer

Doctors now use cancer-killing viruses to treat some patients with lethal, fast-growing brain tumors. Clinical trials show that these therapeutic viruses are safe but less effective than expected.

A new study led by researchers at the Ohio State University Comprehensive Cancer Center ? Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC ? James) shows that the reason for this is in part due to the patient's own immune system, which quickly works to eliminate the anticancer virus.

The findings, published in the journal Nature Medicine, show that the body responds to the anticancer virus as it does to an infection. Within hours, specialized immune cells called natural killer (NK) cells move in to eliminate the therapeutic virus in the brain.

The researchers discovered that the NK cells attack the viruses when they express specific molecules on their surface called NKp30 and NKp46. "These receptor molecules enable the NK cells to recognize and destroy the anticancer viruses before the viruses can destroy the tumor," says co-senior author Dr. Michael A. Caligiuri, director of Ohio State's Comprehensive Cancer Center and CEO of the James Cancer Hospital and Solove Research Institute, and a senior author of the study.

"When we blocked those receptors, the virus has more time to work, and mice with these brain tumors live longer. The next step is to block these molecules on NK cells in glioblastoma patients and see if we can improve their outcome," says Caligiuri, who is also the John L. Marakas Nationwide Insurance Enterprise Foundation Chair in Cancer Research. This study of cancer-cell-killing, or oncolytic, viruses is an example of the value of translational research, in which a problem observed during clinical trials is studied in the laboratory to devise a solution.

"In this case, clinical trials of oncolytic viruses proved safe for use in the brain, but we noticed substantial numbers of immune cells in brain tumors after treatment," says senior author and neurosurgeon Dr. E. Antonio Chiocca, who was professor and chair of neurological surgery while at Ohio State University.

"To understand this process, we went back to the laboratory and showed that NK cells rapidly infiltrate tumors in mice that have been treated with the therapeutic virus. These NK cells also signal other inflammatory cells to come in and destroy the cancer-killing virus in the tumor."

The study used an oncolytic herpes simplex virus, human glioblastoma tumor tissue and mouse models, one of which hosted both human glioblastoma cells and human NK cells. Key technical findings include:

  • Replication of the therapeutic virus in tumor cells in an animal model rapidly attracted subsets of NK cells to the tumor site;
  • NK cells in tumors activated other immune cells (i.e., macrophages and microglia) that have both antiviral and anticancer properties;
  • Depletion of NK cells improves the survival of tumor-bearing mice treated with the therapeutic virus;
  • NK cells that destroy virus-infected tumor cells express the NKp30 and NKp46 receptors molecules that recognize the virus.
"Once we identify the molecules on glioblastoma cells that these NK cell receptors bind with, we might be able to use them to identify patients who will be sensitive to this therapy," Caligiuri says.

Journal reference: Nature Medicine

Provided by Ohio State University Medical Center

Source: http://medicalxpress.com/news/2012-11-patient-immune-cells-blunt-viral.html

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Singletrack mindfulness: Jenn & Jennie: Mountain bike and Yoga ...

The hall of fame likes to showcase women involved in mountain biking from across the globe.

Jenn and Jennie run Singletrack Mindfulness; a mountain bike and yoga retreat in Vermont. We caught up with them to find out a bit more about what they do?

Name: Jenn Childress

Nickname(s): Ms. C (I?m a middle school teacher.) Chills ? There are too many Jenns in the world.

Age:? 32

Lives:? Burlington, Vermont, USA

Rides: Specialized Safire FSR Elite

?

Tell us a little about yourself:

I love riding my bike! When I?m not teaching middle school kids how to read and write, I am riding my bike or thinking about riding my bike. ?I grew up in Virginia playing? team sports like basketball and softball, but I grew disillusioned with them as an adult. I needed a way to stay in shape and still have fun. Enter -mountain biking.

Jenn

How come you decided to set up a mountain bike and yoga business?

Jennie told me about her idea, and I realized the potential in it. Mountain biking, although fun, can take a toll on your body.? I realized that the combination of yoga and mountain biking helped improve my recovery time and my overall fitness.? Yoga helps you improve skills such as balance as well as work on mental obstacles like fear.? I also believe that combining the two practices will help riders extend the longevity of their mountain biking by maintaining their bodies.

If we were to learn one yoga move, which one would you recommend?

Standing Forward Fold (Uttanasana)- My back and shoulders often get really tight and sore after riding.? The standing forward fold helps to reduce pain in your back and increase flexibility in your hamstrings and hip flexors.? You can add more intensity by grasping a strap or clasping your hands behind your back to open up your chest even more.

On the trails

What could we expect from a Singletrack Mindfulness holiday?

You could expect to leave your worries behind and really unplug for the duration of your retreat.? We take care of everything including your meals, transportation, guiding, yoga instruction, and bike care.? We?ve done enough of our own bike trips to recognize where time and money is wasted. Our goal is to ensure that guests have a chance to enjoy their vacations while spending more time biking and practicing yoga and not thinking so much about details like where to stay and what to eat.

What?s the riding like in your neck of the woods?

There are a lot of steep up and down transitions. Trails have many technical sections using natural obstacles like roots, rocks, and other terrain features both up and down hill.? Some trails feature numerous rock rollers and little hucks as well as rock piles and something I like to call ?spiderweb? roots.? The ?spiderweb? roots are smaller root systems that cover an entire area like a web and can be quite challenging when they?re slick.

Technical sections

When/How did you get into riding?

Eight years ago I started doing some bike commuting when I lived in Chicago. ?I read about a mountain bike hut-to-hut trip in Colorado and Utah, and I decided I wanted to do it. ?I called up a couple of my best friends from college and recruited them for the ride.? We did the trip ? 250 miles from Telluride to Moab, and that?s when I fell in love with singletrack!

I love riding because?

it makes me feel like a kid.? I have so much fun on the bike and with my friends. It keeps me in shape and helps reduce my stress in a healthy way.? It also provides a unique way to experience the earth?s terrain.? You get to flow with it rather than tread upon it and that just feels so good!

Top 3 Riding Spots

  • Black Mountain, Pisgah National Forest in North Carolina ? This ride is sick!
  • Kingdom Trails in East Burke, Vermont ? Of course!
  • Doctor Park in Crested Butte, Colorado ? It?s like being a Jedi on that trail!

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Jennie and Jenn

Name: Jennie Date

Nickname(s): Jennie Date

Age:? 38

Lives:? Burlington, Vermont, USA

Rides: Santa Cruz Blur LT

Tell us a little about yourself:

I was born in the UK and grew up in California, now I live in Vermont, which has elements of both and is also totally unique.? I love to spend as much time as possible outdoors, and I co-habitate with a really cool cat named BB.? Besides the obsessive mountain biking and a deep devotion to yoga, I dig making plant medicines, studying astrology, enjoying good beer, consuming local food and working with youth.

Jennie checking out the view

How come you decided to set up a mountain bike and yoga business?

I?ve tried many different careers ? wine buyer, naturalist, youth worker, carpenter, road bike tour leading ? struggling to figure out what I should do for a ?career.?? Through all those changes, I always rode my bike ? the one constant ? and built my schedule around it.? About 5 years into my recreational mountain biking career, I started doing yoga. Yoga allowed me to confront physical and mental obstacles, creating a new sense of confidence and balance.? Combine that with the amazing power of going on retreat, and I just thought I should share.

If we were to learn one yoga move, which one would you recommend?

If I were stranded on a desert island and could only bring one yoga pose? it would be downward-facing dog (Adho Mukha Shvanasana).? Downward Dog is an overall body stretch, opening the entire backside of the body and at the same time dynamically strengthening the upper body. The spine lengthens and the entire body is rejuvenated. In a way, it?s a bit of a ?do-all? pose:? part inversion, part hip/shoulder opener, part forward bend, with even a suggestion of a back bend in between the shoulder blades.? It also can serve as either a challenging pose, or a restful one.

Mid ride, downward dog break

What could we expect from a Singletrack Mindfulness holiday?

You could expect to feel completely relaxed and rejuvenated.? The balance of the physical exertion of mountain biking and the inner reflection of yoga practically guarantees an experience that is both exhilarating and deeply restful.? Vermont is beautiful and quiet and also makes some good ale. You can expect to have a lot of fun, good laughs, and some actual time to yourself!? And you?ll feel like a badass!

What?s the riding like in your neck of the woods?

The riding in Vermont is amazing.? In the last decade, some very dedicated trail builders have taken over the scene and now there are hundreds of miles of winding, challenging, incredible singletrack, built by mountain bikers, for mountain bikers.? The views are spectacular and there are loads of swimming holes to cool off in too.? The terrain is varied, making excellent use of local rock for stunts.? It is technical, demanding, and extremely rewarding.

The rock strewn trails

When/How did you get into riding?

I started riding at age 7 in my driveway, determined to learn without training wheels.? Years later, I picked up mountain biking while going to college in Montana, while feeling somewhat disillusioned by academia; I was studying plants, but couldn?t understand why we weren?t spending more time outdoors.? Mountain biking became the way I connected with the wilderness.


I love riding because?

It has brought me friends, solitude, fitness, connection to the outdoors, community, sweet travel opportunities, a vocation, and a way to overcome obstacles in life.? Additionally, it has connected me with my lifelong partner and companion ? now that can?t be beat!

Top 3 Riding Spots

  • Waterbury, Vermont
  • The Preacher, Hinesburg, Vermont
  • Zippety Do Da, Fruita, Colorado

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Find out more about Singletrack Mindfulness retreats here.

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Source: http://www.girlmtnbiker.com/singletrack-mindfulness-jenn-jennie-mountain-bike-and-yoga-retreat-owners/

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